解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In contextual fear conditioning (CFC), hippocampus is thought to process environmental stimuli into a configural representation of the context and send it to amygdala nuclei, which current evidences point to be the site of CS-US association and fear memory storage. If it is true, hippocampus should influence learning-...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22118
更新日期:2013-07-01 00:00:00
abstract::Nuclear factor-kappa B (NFκB) signal is essential for neuronal survival and its activation may protect neuron against various stimuli. Since purinergic signals activate NFκB through the P2X7 receptor, we investigated the distinct pattern of NF-κB phosphorylation in neurons by P2X7 receptor activation following status ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22109
更新日期:2013-06-01 00:00:00
abstract::The aim of this study was to investigate the role of the human hippocampus in episodic retrieval of odors, in comparison with episodic retrieval of visual objects. Subjects encoded a set of unique odors and objects, and retrieval was tested the next day during functional magnetic resonance imaging (fMRI). Subjects wer...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22073
更新日期:2013-02-01 00:00:00
abstract::There is extensive research regarding the neural mechanisms involved in satiety and meal termination; in contrast, there is very limited understanding of how meal onset is regulated. On the basis of several converging lines of evidence, we hypothesized that hippocampal neurons form a memory of a meal and inhibit meal ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22062
更新日期:2013-01-01 00:00:00
abstract::Highly synchronized neural firing has been discussed in relation to learning and memory, for instance sharp-wave activity in hippocampus. We were interested to study how a postsynaptic CA1 pyramidal neuron would integrate input of different levels of synchronicity. In previous work using computational modeling we stud...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22061
更新日期:2013-01-01 00:00:00
abstract::Effective navigation depends upon reliable estimates of head direction (HD). Visual, vestibular, and outflow motor signals combine for this purpose in a brain system that includes dorsal tegmental nucleus, lateral mammillary nuclei, anterior dorsal thalamic nucleus, and the postsubiculum. Learning is needed to combine...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22040
更新日期:2012-12-01 00:00:00
abstract::The molecular mechanisms of regionalization of the medial pallium (MP), the anlage of the hippocampus, and transitional (cingulate and retrosplenial) cortices are largely unknown. Previous analyses have outlined an important role of the transcription factor (TF) Zbtb20 for hippocampal CA1 field specification (Nielsen ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22035
更新日期:2012-11-01 00:00:00
abstract::Increased consumption of high-fat diet (HFD) leads to obesity and adverse neurocognitive outcomes. Childhood and adolescence are important periods of brain maturation shaping cognitive function. These periods could consequently be particularly sensitive to the detrimental effects of HFD intake. In mice, juvenile and a...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22032
更新日期:2012-11-01 00:00:00
abstract::Previous work has shown that immunohistochemical imaging of Fos protein is a reliable marker for changes in activity related to recognition memory in the perirhinal (PRH) cortex of the medial temporal lobe; however, whether PRH Fos expression is necessary for recognition memory had not been established. To investigate...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22028
更新日期:2012-11-01 00:00:00
abstract::The perirhinal cortex (PRC) is known to play an important role in object recognition. Little is known, however, regarding the activity of PRC neurons during the presentation of stimuli that are commonly used for recognition memory tasks in rodents, that is, three-dimensional objects. Rats in the present study were exp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22060
更新日期:2012-10-01 00:00:00
abstract::This study examined the ability of cognitively normal young adults (n = 30) and older adults (n = 30) to perform a delayed match-to-sample task involving varying degrees of spatial interference to assess spatial pattern separation. Each trial consisted of a sample phase followed by a choice phase. During the sample ph...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.22017
更新日期:2012-09-01 00:00:00
abstract::Deficits in episodic memory are associated with deficits in the ability to imagine future experiences (i.e., mental time travel). We show that K.C., a person with episodic amnesia and an inability to imagine future experiences, nonetheless systematically discounts the value of future rewards, and his discounting is wi...
journal_title:Hippocampus
pub_type: 杂志文章,随机对照试验
doi:10.1002/hipo.20981
更新日期:2012-06-01 00:00:00
abstract::Fear can be extinguished by repeated exposure to a cue that signals threat. However, extinction does not erase fear, as an extinguished cue presented in a context distinct from that of extinction results in renewed fear of that cue. The hippocampus, which is involved in the formation of contextual representations, is ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20954
更新日期:2012-05-01 00:00:00
abstract::The hippocampus and the medial temporal lobe cortex [medial temporal lobe cortices (MTLC)] both contribute to long-term memory. Although their contributions are thought to be dissociable, the nature of the representations that each region supports remains unclear. The Complementary Learning Systems (CLS) modeling appr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20967
更新日期:2012-05-01 00:00:00
abstract::Alzheimer's disease (AD) and ageing are associated with impaired learning and memory, and recent findings point toward modulating chromatin remodeling through histone acetylation as a promising therapeutic strategy. Here we report that systemic administration of the HDAC inhibitor 4-phenylbutyrate (PBA) reinstated fea...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20883
更新日期:2012-05-01 00:00:00
abstract::The importance of the hippocampal theta oscillation (4-8 Hz) to memory formation has been well-established through studies in animals, prompting researchers to propose comprehensive theories of memory and learning that rely on theta oscillations for integrating information in the hippocampus and neocortex. Yet, empiri...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20937
更新日期:2012-04-01 00:00:00
abstract::Early life stress predisposes to the development of psychiatric disorders. In this context the hippocampal formation is of particular interest, because it is affected by stress on the structural and cognitive level. Since little is known how early life stress is translated on the molecular level, we mimicked early lif...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20907
更新日期:2012-03-01 00:00:00
abstract::Multiple factors are involved in the glutamate-induced excitotoxicity phenomenon, such as overload of ionotropic and metabotropic receptors, excess Ca(2+) influx, nitric oxide synthase activation, oxidative damage due to increase in free radicals, and release of endogenous polyamine, among others. In order to attempt ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20869
更新日期:2012-02-01 00:00:00
abstract::Schizophrenia is a devastating psychiatric illness with a complex pathophysiology. We have recently documented schizophrenia-like endophenotypes in phospholipase C-β1 knockout (PLC-β1(-/-)) mice, including deficits in prepulse inhibition, hyperlocomotion, and cognitive impairments. PLC-β1 signals via multiple G-protei...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20900
更新日期:2012-02-01 00:00:00
abstract::The induction of long-lasting memory storage depends on the behavioral state of humans and animals. This behavioral state is mediated by neuromodulatory systems, like the cholinergic-septum-hippocampal circuit. Cholinergic neurotransmission is known to affect short-term activity-dependent plasticity in various brain a...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20902
更新日期:2012-02-01 00:00:00
abstract::The hippocampus receives two streams of information, spatial and nonspatial, via major afferent inputs from the medial (MEC) and lateral entorhinal cortexes (LEC). The MEC and LEC projections in the temporoammonic pathway are topographically organized along the transverse-axis of area CA1. The potential for functional...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20909
更新日期:2012-02-01 00:00:00
abstract::Throughout the adult life of most mammals, new neurons are continuously generated in the dentate gyrus of the hippocampal formation. Recent work has documented specific cognitive deficits after elimination of adult hippocampal neurogenesis in rodents, suggesting that these neurons may contribute to information process...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20860
更新日期:2012-01-01 00:00:00
abstract::Changes in synaptic efficacy and morphology have been proposed as mechanisms underlying learning and memory processes. In our previous studies, high frequency stimulation (HFS) sufficient to induce LTP at the hippocampal mossy fiber (MF) pathway, leads to MF synaptogenesis, in a prominent contralateral form, at the st...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20866
更新日期:2012-01-01 00:00:00
abstract::Stratum lacunosum-moleculare interneurons (L-Mi) in hippocampal area CA3 target the apical dendrite of pyramidal cells providing feedforward inhibition. Here we report that selective activation of group III metabotropic glutamate receptors (mGluRs) 4/8 with L(+)-2-amino-4-phosphnobytyric acid (L-AP4; 10 μM) decreased ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20842
更新日期:2011-12-01 00:00:00
abstract::Studies of the neuropharmacological substrates of spatial memory formation have focused on the contribution of septohippocampal pathways. Although these pathways include, among others, cholinergic and GABAergic fibers innervating the hippocampus, research has essentially been oriented towards the role of their choline...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20837
更新日期:2011-12-01 00:00:00
abstract::Although the importance of cAMP-response element binding protein (CREB) phosphorylation in long-term memory formation is well documented for hippocampus-dependent tasks, little is known about the changes in phosphorylated CREB (pCREB) that occur during the process of extinction. The purpose of this study was to charac...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20844
更新日期:2011-11-01 00:00:00
abstract::Recent studies have demonstrated that remembering past experiences and imagining future scenarios recruits a core network including the hippocampus. Even so, constructing future events engages the hippocampus more than remembering past events. This fMRI study examined whether increased hippocampal activity for future ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20870
更新日期:2011-10-01 00:00:00
abstract::Recent evidence suggests that activity-regulated cytoskeleton associated protein (Arc) and brain-derived neurotrophic factor (BDNF) are key players in the cellular mechanisms that trigger synaptic changes and memory consolidation. Cholinergic deafferentiation of hippocampus has been largely shown to induce memory impa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20812
更新日期:2011-09-01 00:00:00
abstract::There is an ongoing debate regarding the respective role of anterior subhippocampal structures and the hippocampus in recognition memory. Here, we report a double anatomo-functional dissociation observed in two brain-damaged patients, FRG and JMG. They both suffered from complete destruction of left MTL structures. In...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20848
更新日期:2011-09-01 00:00:00
abstract::Although it is well established that the integrity of the medial temporal lobe (MTL) is critical for declarative memory, the functional organization of the MTL remains a matter of intense debate. One issue that has received little consideration so far is whether the hippocampus can function normally in the presence of...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20800
更新日期:2011-08-01 00:00:00
abstract::To ask if the properties of spatial learning supported by the hippocampus are distinct from the properties of conditioning, we conducted a blocking-like experiment in which the measured variable was not a conditioned response but rather the ability of a novel visual stimulus to control the location of place cell firin...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20764
更新日期:2011-05-01 00:00:00
abstract::Both natural and synthetic cannabinoid receptor (e.g., CB1) agonists such as Δ(9)-THC, WIN 55,212-2 (WIN-2), and HU-210 disrupt spatial cognition presumably through the inhibition of synchrony of hippocampal ensemble firing to task-related events. Although the CB1 receptor agonist CP 55,940 also disrupts the synchrono...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20769
更新日期:2011-05-01 00:00:00
abstract::In rodents, chronic stress induces long-lasting structural and functional alterations in the hippocampus, as well as learning and memory impairments. The neural cell adhesion molecule (NCAM) was previously hypothesized to be a key molecule in mediating the effects of stress due to its role in neuronal remodeling and s...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20723
更新日期:2011-01-01 00:00:00
abstract::Recent observations have caused a drastic shift in the conception of the hippocampus as a homogeneous structure that subserves cognitive functions, either spatial maps or short term episodic memory, to a structure that is associated with both cognitive and emotional functions. In fact, the assignment of cognitive func...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20751
更新日期:2010-12-01 00:00:00
abstract::The growth arrest specific 5 (gas5) is a noncoding protein gene that hosts small nucleolar RNAs. Based on the observation that gas5 RNA level in the brain is highest in the hippocampus and remarkably enhanced in aged mice, we tested the hypothesis that gas5 is involved in functions controlled by the hippocampus and kn...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20701
更新日期:2010-09-01 00:00:00
abstract::As part of an earlier experiment (Kwok and Buckley, 2009), six macaque monkeys (three with fornix transection and three unoperated controls) were trained postoperatively to discriminate a total of 104 new concurrent visuospatial conditional problems to criterion. Our experiment measured and compared long-term retentio...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20733
更新日期:2010-08-01 00:00:00
abstract::Adult neurogenesis continues throughout life in the mammalian hippocampus. The precise function of the adult generated neurons remains uncertain although there is growing evidence that they are involved in hippocampus-dependent learning and memory. Training rats on a hidden platform version of the Morris water task ha...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20692
更新日期:2010-07-01 00:00:00
abstract::Longitudinal studies on patients for schizophrenia suggest that functional brain perturbations precede the onset of symptoms. Rats with a neonatal ventral hippocampal lesion (NVHL) are considered as a heuristic neurodevelopmental model of schizophrenia. We characterized basal metabolic changes observed in NVHL rats be...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20686
更新日期:2010-07-01 00:00:00
abstract::Neuregulins (NRGs) are ligands of ErbB receptor tyrosine kinases. The NRG1-ErbB4 pathway has been shown to modulate hippocampal synaptic plasticity and network oscillations in the adult rodent brain. To identify cells that mediate these effects, here we determine the expression pattern of ErbB4 in four functionally di...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20675
更新日期:2010-06-01 00:00:00
abstract::Neuropsychological analyses of amnesic patients, as well as lesion experiments, indicate that the temporal lobe is essential for the encoding, storage, and expression of object recognition memory (ORM). However, temporal lobe structures directly involved in the consolidation and reconsolidation of these memories are n...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20669
更新日期:2010-05-01 00:00:00